This paper examines the impact of climate change on children’s health in the Limpopo province of South Africa. Over 20 years of data were collected to analyse climatic conditions in the province. The study employs regression analysis to examine the relationships between climatic parameters and incidence of diseases, and to predict distribution of diseases by 2050. The results show that the most prevalent diseases were diarrhoea, followed by respiratory infection, asthma and malaria. The most tropical location, Mussina, had the highest incidence of the most prevalent disease, diarrhoea, with 59.4 per cent. The analysis shows that maximum temperature is positively correlated with years in four cities, thereby indicating local warming. Similarly rainfall decreased over time in all of the cities. Results of the regression analysis show that 37.9 per cent of disease incidence is accounted for by the combined influence of temperature and rainfall.